Cerebrospinal fluid derived from progressive multiple sclerosis patients promotes neuronal and oligodendroglial differentiation of human neural precursor cells in vitro

@article{Cristofanilli2013CerebrospinalFD,
  title={Cerebrospinal fluid derived from progressive multiple sclerosis patients promotes neuronal and oligodendroglial differentiation of human neural precursor cells in vitro
},
  author={Massimiliano Cristofanilli and Barbara Cymring and Amy Lu and Hannah Rosenthal and Saud A Sadiq},
  journal={Neuroscience},
  year={2013},
  volume={250},
  pages={614-621}
}
In Vivo Administration of Cerebrospinal Fluid of Patients with Multiple Sclerosis; A New Model to Study Adult Neurogenesis in Different Stages ofDisease
TLDR
Administration of CSF derived from patients in to the brain ventricles of mice can lead to an experimental animal model for studying neurogenesis and other pathophysiology of multiple sclerosis, and this strategy will help researchers to unravel the mechanisms in which Neurogenesis changes in different stages of MS disease.
Multiple sclerosis patient-derived CSF induces transcriptional changes in proliferating oligodendrocyte progenitors
TLDR
Despite evidence of morphological differentiation induced by exposure to CSF of PPMS patients, the overall transcriptional response elicited in cultured OPCs was consistent with the activation of an aberrant transcriptional programme.
Cerebrospinal fluid-stem cell interactions may pave the path for cell-based therapy in neurological diseases
TLDR
The relative literature on the influence of the CSF on stem cells is reviewed in order to provide a more comprehensive reference for the wide clinical application of NSCs in the future.
Stem Cell Therapy for Multiple Sclerosis: An Exciting Challenge or a Treatment Hope
TLDR
Recent research suggests and hopes that stem cell therapy will develop and propose a new and safe treatment approach to various diseases, especially neurodegenerative disorders such as MS in the near future, but the results of a recent trial showed that this method only helped to improve the symptoms of approximately half the enrolled patients.
Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies
TLDR
The MHV model of demyelination presents a relevant mouse model to assess the therapeutic potential of NPCs transplanted into an environment in which inflammatory-mediated demyELination is established.
The cerebrospinal fluid-stem cell interactions as target for regenerative therapy in neurological diseases.
TLDR
In multiple sclerosis (MS), especially progressive MS, the patient’s CSF demonstrated reduced the proliferation of NSCs and affected their differentiation in vitro, and hydrocephalus, the accumulation of CSF fluid with distention of the ventricular walls, modifies the composition of the CSF with inflammatory markers and the SVZ, leading to reduction of proliferation ofNSCs.
Cultivation and Neural Differentiation of Embryonic Cerebrospinal Fluid Treated Adipose Stem Cells on the Scaffold of Amniotic Membrane
TLDR
Cultivation of ASCs on the scaffold and their treatment with CSF induced them into the neural lineage fate in the absence of any chemical inducing factor, suggesting this method of co-culture may represent a new method to improve in vitro neural differentiation of ASC's.
Results from Phase I Clinical Trial with Intraspinal Injection of Neural Stem Cells in Amyotrophic Lateral Sclerosis: A Long‐Term Outcome
TLDR
The results show that transplantation of hNSC is a safe procedure that causes no major deleterious effects over the short or long term, and the observations support undertaking future phase II clinical studies in which increased cell dosages are studied in larger cohorts of patients.
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