Cerebrospinal fluid cortisol concentrations in healthy elderly are affected by both APOE and TOMM40 variants.

@article{Bruno2012CerebrospinalFC,
  title={Cerebrospinal fluid cortisol concentrations in healthy elderly are affected by both APOE and TOMM40 variants.},
  author={Davide Bruno and Jay J. Nierenberg and James Carl Ritchie and Michael W. Lutz and Nunzio Pomara},
  journal={Psychoneuroendocrinology},
  year={2012},
  volume={37 3},
  pages={366-71}
}
Abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis have been reported in subjects with Alzheimer's disease (AD) and may include increased cerebrospinal fluid (CSF) cortisol concentrations. Moreover, presence of the APOE ɛ4 allele, which is an established risk factor for the development of AD, has been shown to associate with higher CSF cortisol levels, especially in AD sufferers. In this study, we examined whether TOMM40 variants, which have been reported to influence age of onset… CONTINUE READING