Cerebrospinal fluid concentrations of gefitinib in patients with lung adenocarcinoma.

Abstract

BACKGROUND Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib, have high response and disease control rates in patients with central nervous system (CNS) metastases. However there have been only a few case reports on the penetration of gefitinib into the cerebrospinal fluid (CSF). The aim of this study… (More)
DOI: 10.1016/j.cllc.2012.06.004

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