Cerebrospinal fluid concentrations of atracurium, laudanosine and vecuronium following clinical subarachnoid hemorrhage.

@article{Tassonyi2002CerebrospinalFC,
  title={Cerebrospinal fluid concentrations of atracurium, laudanosine and vecuronium following clinical subarachnoid hemorrhage.},
  author={Ed{\"o}m{\'e}r Tassonyi and Mohammad Fathi and Graeme J. Hughes and Florence Chiodini and Daniel Bertrand and Dominique Muller and Thomas Fuchs-Buder},
  journal={Acta anaesthesiologica Scandinavica},
  year={2002},
  volume={46 10},
  pages={1236-41}
}
BACKGROUND Neuromuscular blocking agents may exert central nervous system effects when they reach the brain. This study assessed the concentrations and the time course of passage of vecuronium, atracurium, and its metabolite laudanosine in the cerebrospinal fluid (CSF) of patients undergoing intracranial aneurysm clipping. METHODS Twenty-five patients… CONTINUE READING