Cerebrospinal fluid biomarkers for Alzheimer’s disease: the role of apolipoprotein E genotype, age, and sex

@inproceedings{Mehrabian2015CerebrospinalFB,
  title={Cerebrospinal fluid biomarkers for Alzheimer’s disease: the role of apolipoprotein E genotype, age, and sex},
  author={Shima Mehrabian and Panagiotis Alexopoulos and Marion Ortner and Latchezar Dintchov Traykov and Timo Grimmer and Alexander Kurz and Hans F{\"o}rstl and Horst Bickel and Janine Diehl-Schmid},
  booktitle={Neuropsychiatric disease and treatment},
  year={2015}
}
INTRODUCTION Cerebrospinal fluid (CSF) biomarkers improve the diagnostic accuracy for Alzheimer's disease (AD), even at the predementia stage of the disease. The ε4-allele of apolipoprotein E (ApoE ε4), female sex, and older age are well-known risk factors for AD. It is unclear how these risk factors affect the CSF biomarkers in patients with AD. AIM The objective of this study was to investigate the associations of ApoE ε4, sex, and age with CSF biomarker levels in a unicenter sample of… CONTINUE READING
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