Cerebrospinal fluid and serum levels and intrathecal production of active matrix metalloproteinase-9 (MMP-9) as markers of disease activity in patients with multiple sclerosis.

@article{Fainardi2006CerebrospinalFA,
  title={Cerebrospinal fluid and serum levels and intrathecal production of active matrix metalloproteinase-9 (MMP-9) as markers of disease activity in patients with multiple sclerosis.},
  author={Enrico Fainardi and Massimiliano Castellazzi and Tiziana Bellini and Maria Cristina Manfrinato and Eleonora Baldi and Ilaria Casetta and Ezio Paolino and Enrico Granieri and Franco Dallocchio},
  journal={Multiple sclerosis},
  year={2006},
  volume={12 3},
  pages={294-301}
}
In this study, we employed a sensitive activity assay system to measure cerebrospinal fluid (CSF) and serum levels of active matrix metalloproteinase-9 (MMP-9) in 37 relapsing-remitting (RR), 15 secondary progressive (SP) and nine primary progressive (PP) multiple sclerosis (MS) patients, grouped according to clinical and magnetic resonance imaging (MRI) evidence of disease activity. We also studied, as neurological controls, 48 patients with other inflammatory neurological disorders (OIND) and… CONTINUE READING
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