Cerebrospinal fluid and plasma leptin measurements: covariability with dopamine and cortisol in fasting humans.

@article{Hagan1999CerebrospinalFA,
  title={Cerebrospinal fluid and plasma leptin measurements: covariability with dopamine and cortisol in fasting humans.},
  author={Mary M Hagan and P. Havel and Randy J Seeley and Stephen Woods and Nosakhare N Ekhator and Dewleen G. Baker and Kelly Kearfott Hill and Matt D Wortman and Andrew H. Miller and Ronald L. Gingerich and Thomas D. Geracioti},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 10},
  pages={3579-85}
}
Leptin (OB protein) is an important signal in the regulation of energy balance. Leptin levels correlate with adiposity, but also decrease acutely with caloric restriction and increase with refeeding. The brain is an established critical site of leptin function, yet little is known about leptin concentrations in the central nervous system relative to plasma levels, psychiatric diagnoses, and other endocrine parameters. Therefore, using a novel ultrasensitive leptin assay, we explored… CONTINUE READING