Cerebrospinal fluid T cell responses against glutamic acid decarboxylase 65 in patients with stiff person syndrome.

@article{Skorstad2009CerebrospinalFT,
  title={Cerebrospinal fluid T cell responses against glutamic acid decarboxylase 65 in patients with stiff person syndrome.},
  author={Gjertrud Skorstad and Anne Lise Karlsgot Hestvik and Frode Vartdal and Trygve Holm\oy},
  journal={Journal of autoimmunity},
  year={2009},
  volume={32 1},
  pages={24-32}
}
Most patients with stiff person syndrome (SPS) display intrathecal synthesis of oligoclonal and high-avidity IgG against the 65 kDa isoform of glutamic acid decarboxylase (GAD65 IgG), but little is known about the mechanisms driving this immune response. We hypothesized that GAD65-specific T cells accumulating in the central nervous system drive the intrathecal GAD65 IgG production. Accordingly, we were able to clone HLA-DR or DP restricted GAD65-specific T cells from the cerebrospinal fluid… CONTINUE READING
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