Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection.

@article{Harp2007CerebrospinalFB,
  title={Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection.},
  author={Christopher T Harp and Jane HyoJin Lee and Doris Lambracht-Washington and Elizabeth M Cameron and Gregory Olsen and Elliot M. Frohman and Michael Karl Racke and Nancy Monson},
  journal={Journal of neuroimmunology},
  year={2007},
  volume={183 1-2},
  pages={189-99}
}
Previous findings from our laboratory demonstrated that some clonally expanded cerebrospinal fluid (CSF) B cells from MS patients exhibit diminished mutation targeting patterns in comparison to typical B cells selected in the context of germinal centers (GCs). In order to determine whether the overall CSF B cell repertoires adhered to mutation patterns typical of GC-selected B cells, we analyzed the immunoglobulin repertoires from CSF B cells of 8 MS patients for mutation characteristics… CONTINUE READING
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