Cerebrospinal Fluid Metabolome in Mood Disorders-Remission State has a Unique Metabolic Profile

@inproceedings{KaddurahDaouk2012CerebrospinalFM,
  title={Cerebrospinal Fluid Metabolome in Mood Disorders-Remission State has a Unique Metabolic Profile},
  author={Rima Kaddurah-Daouk and Peixiong Yuan and Stephen H. Boyle and Wayne R. Matson and Zhi Wang and Zhao Bang Zeng and Hongjie Zhu and George G. Dougherty and Jeffrey Yao and Guang Chen and Xavier Guitart and Paul J. Carlson and Alexander Neumeister and Carlos A. Zarate and Ranga K. R. Krishnan and Husseini K. Manji and Wayne C. Drevets},
  booktitle={Scientific reports},
  year={2012}
}
Targeted metabolomics provides an approach to quantify metabolites involved in specific molecular pathways. We applied an electrochemistry-based, targeted metabolomics platform to define changes in tryptophan, tyrosine, purine and related pathways in the depressed and remitted phases of major depressive disorder (MDD). Biochemical profiles in the cerebrospinal fluid of unmedicated depressed (n = 14; dMDD) or remitted MDD subjects (n = 14; rMDD) were compared against those in healthy controls (n… CONTINUE READING

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