Cerebrospinal Fluid Markers in Sporadic Creutzfeldt-Jakob Disease

  title={Cerebrospinal Fluid Markers in Sporadic Creutzfeldt-Jakob Disease},
  author={Gianluigi Zanusso and Michele Fiorini and Sergio Ferrari and Alberto Gajofatto and Annachiara Cagnin and Andrea Galassi and Silvia Richelli and Salvatore Monaco},
  booktitle={International journal of molecular sciences},
Sporadic Creutzfeldt-Jakob disease (sCJD) is the commonest form of human prion diseases, accounting for about 85% of all cases. Current criteria for intra vitam diagnosis include a distinct phenotype, periodic sharp and slow-wave complexes at electroencephalography (EEG), and a positive 14-3-3-protein assay in the cerebrospinal fluid (CSF). In sCJD, the disease phenotype may vary, depending upon the genotype at codon 129 of the prion protein gene (PRNP), a site of a common methionine/valine… CONTINUE READING
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Molecular mechanisms of human prion diseases

  • G. Zanusso, S. Monaco
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