Cerebrospinal Fluid Homovanillic Acid Predicts Behavioral Response to Stimulants in 45 Boys with Attention Deficit/Hyperactivity Disorder

@article{Castellanos1996CerebrospinalFH,
  title={Cerebrospinal Fluid Homovanillic Acid Predicts Behavioral Response to Stimulants in 45 Boys with Attention Deficit/Hyperactivity Disorder},
  author={F. Xavier Castellanos and Josephine Elia and Markus J P Kruesi and Wendy L Marsh and Charles S Gulotta and William Z. Potter and Gail F Ritchie and Susan D Hamburger and Judith L. Rapoport},
  journal={Neuropsychopharmacology},
  year={1996},
  volume={14},
  pages={125-137}
}
Central dopaminergic activity has been assumed to play a role in the efficacy of stimulant drugs in attention deficit/hyperactivity disorder (ADHD), although supporting evidence has been scant. This study examined baseline cerebrospinal fluid (CSF) of boys with ADHD in relation to response to three different stimulant drugs. Forty five boys with DSM-III-R-diagnosed ADHD had a lumbar puncture before double-blind trials of methylphenidate, dextroamphetamine, and placebo. Sixteen also received… CONTINUE READING