Cerebromicrocirculatory defects in animal model of depression

  title={Cerebromicrocirculatory defects in animal model of depression},
  author={Sheldon H. Preskorn and Thomas A. Kent and Robin K. Glotzbach and George H. Irwin and Jay V. Solnick},
In the tetrabenazine (TBZ) model of depression, the cerebromicrocirculation was discovered to respond abnormally to metabolic demand as mimicked by the administration of CO2. Altered responsivity of cerebral blood flow and effective permeability of the blood — brain barrier to changes in PaCO2 were found. These physiologic defects coincided temporally with TBZ-induced depletion of central norepinephrine and dopamine and with the development of the behavioral effects of TBZ (the end points used… CONTINUE READING
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