Cerebrodiene: a brain lipid isolated from sleep-deprived cats.

  title={Cerebrodiene: a brain lipid isolated from sleep-deprived cats.},
  author={Richard Allen Lerner and Gary Siuzdak and O Prosp{\'e}ro-garc{\'i}a and Steven J. Henriksen and Dale L. Boger and Benjamin F Cravatt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={91 20},
We report the isolation of a heretofore unrecognized brain lipid that is present in cerebrospinal fluid of sleep-deprived cats. The molecule appears to be a long-chain base structurally related to sphingosine and sphinganine in which a second unsaturated bond has been introduced. An increase in the degree of unsaturation of a key membrane component is expected to have important physiological consequences. 

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Anesthesia (Churchill

  • Y. A. Hannun
  • J. Biol. Chem
  • 1994

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