Cerebral white matter damage in HIV infection demonstrated using β-amyloid precursor protein immunoreactivity

@article{Raja1997CerebralWM,
  title={Cerebral white matter damage in HIV infection demonstrated using β-amyloid precursor protein immunoreactivity},
  author={Faisal M Raja and F. E. Sherriff and Christine S. Morris and L. R. Bridges and Margaret M. Esiri},
  journal={Acta Neuropathologica},
  year={1997},
  volume={93},
  pages={184-189}
}
We have examined brain sections from 55 autopsy cases of AIDS for the prevalence and severity of axonal damage, assessed using β-amyloid precursor protein (βAPP) immunoreactivity as a marker of such damage. The cases were subdivided into cases with HIV encephalitis with multinucleated giant cells (MGC), cases with other specific pathology, such as cerebral toxoplasmosis or lymphoma, cases with non-specific pathology and cases with no pathology. Significantly more foci containing βAPP+ axons… CONTINUE READING
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