Cerebral white matter changes and rate of progression of dementia during cholinesterase inhibitor treatment: a retrospective cohort study.

@article{Devine2007CerebralWM,
  title={Cerebral white matter changes and rate of progression of dementia during cholinesterase inhibitor treatment: a retrospective cohort study.},
  author={Mike Devine and Jose A. S. Fonseca and Rodney W. H. Walker and T K Sikdar and Tim Stevens and Zuzana Walker},
  journal={International journal of geriatric psychiatry},
  year={2007},
  volume={22 11},
  pages={1120-6}
}
BACKGROUND Cerebral white matter changes (WMC) represent cerebrovascular disease (CVD) and are common in dementia. Cholinesterase inhibitors (ChEIs) are effective in Alzheimer's Disease (AD) with or without CVD, and in Dementia with Lewy Bodies (DLB). Predictors of treatment response are controversial. OBJECTIVE To investigate the effect of WMC severity on rate of progression of dementia during treatment with ChEIs. METHODS CT or MRI brain scans were rated for WMC severity in 243 patients… CONTINUE READING
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