Cerebral vulnerability is associated with selective increase in extracellular glutamate concentration in experimental thiamine deficiency.

@article{Hazell1993CerebralVI,
  title={Cerebral vulnerability is associated with selective increase in extracellular glutamate concentration in experimental thiamine deficiency.},
  author={Alan S. Hazell and Roger F. Butterworth and Antoine M. Hakim},
  journal={Journal of neurochemistry},
  year={1993},
  volume={61 3},
  pages={1155-8}
}
Microdialysis in the awake, freely moving rat was used to determine the effect of pyrithiamine-induced thiamine deficiency on the levels of amino acids in the brain. Studies were carried out on (a) presymptomatic animals immediately before the development of behavioral changes and (b) acute symptomatic animals within 6 h following loss of righting reflexes. This latter stage precedes the appearance of histological lesions. The results were compared with pair-fed controls. Dialysis probes were… CONTINUE READING
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