Cerebral vessel laminins and IFN-gamma define Trypanosoma brucei brucei penetration of the blood-brain barrier.

@article{Masocha2004CerebralVL,
  title={Cerebral vessel laminins and IFN-gamma define Trypanosoma brucei brucei penetration of the blood-brain barrier.},
  author={Willias Masocha and Brita Robertson and Martin E Rottenberg and J D M Mhlanga and Lydia Sorokin and Krister Kristensson},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={114 5},
  pages={689-94}
}
Subspecies of Trypanosoma brucei cause severe brain diseases after penetration of the blood-brain barrier. We investigated whether cytokines that modulate inflammatory cell infiltration into the brain also influence T. brucei neuroinvasion. Migration of a rodent pathogenic T. brucei strain from the cerebral blood vessels into the brain parenchyma was impeded in IFN-gamma(-/-), IFN-gamma receptor(-/-) (IFN-gammaR(-/-)), IL-12p40(-/-), and recombinant activating gene-1(-/-) (RAG-1(-/-)) mice as… CONTINUE READING