Cerebral venous sinus thrombosis: review of the demographics, pathophysiology, current diagnosis, and treatment.

Abstract

Cerebral venous sinus thrombosis (CVST) is a rare clinicopathological entity. The incidence of CVST in children and neonates has been reported to be as high as 7 cases per million people, whereas in adults the incidence is 3-4 cases per million. The predisposing factors to this condition are mainly genetic and acquired prothrombotic states and infection. The clinical picture of CVST is nonspecific, highly variable, and can mimic several other clinical conditions. Diagnosis of CVST is established with the implementation of neuroimaging studies, especially MR imaging and venography. Identification and elimination of the underlying cause, anticoagulation, proper management of intracranial hypertension, and anticonvulsant prophylaxis constitute cornerstones of CVST treatment. Newer treatment strategies such as endovascular thrombolysis and decompressive craniectomy have been recently used in the treatment of patients with CVST with variable success rates. Further clinical research must be performed to delineate the exact role of these newer treatments in the management of severe cases of CVST. The recent advances in the diagnosis and treatment of patients with CVST have significantly lowered the associated mortality and morbidity and have improved the outcome of these patients.

DOI: 10.3171/2009.8.FOCUS09167
020040020102011201220132014201520162017
Citations per Year

1,167 Citations

Semantic Scholar estimates that this publication has 1,167 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Filippidis2009CerebralVS, title={Cerebral venous sinus thrombosis: review of the demographics, pathophysiology, current diagnosis, and treatment.}, author={Aristotelis Stamatios Filippidis and Eftychia Z. Kapsalaki and Gianna Patramani and Konstantinos Fountas}, journal={Neurosurgical focus}, year={2009}, volume={27 5}, pages={E3} }