Cerebral transport and metabolism of 1-11C-D-glucose during stepped hypoglycemia.

@article{Powers1995CerebralTA,
  title={Cerebral transport and metabolism of 1-11C-D-glucose during stepped hypoglycemia.},
  author={William G. Powers and Samuel Dagogo-Jack and Joanne Markham and Kyle Larson and Carmen S. Dence},
  journal={Annals of neurology},
  year={1995},
  volume={38 4},
  pages={599-609}
}
Attempts to measure blood-to-brain glucose transport and cerebral glucose metabolism with 11C-glucose have been hampered by methods that require jugular venous sampling or do not adequately account for the efflux of labeled metabolites from the brain. We performed eight positron emission tomography studies with 1-11C-D-glucose in macaques at arterial plasma glucose concentrations of 8.43 to 1.51 mumol ml-1 (152-27 mg dl-1) using a model that includes a fourth rate constant to account for… CONTINUE READING