Cerebral toxicity of the trichothecene toxin T-2, of the products of its hydrolysis and of some related toxins.

@article{Bergmann1988CerebralTO,
  title={Cerebral toxicity of the trichothecene toxin T-2, of the products of its hydrolysis and of some related toxins.},
  author={Felix Bergmann and Dov Soffer and Boris Yagen},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={1988},
  volume={26 10},
  pages={923-30}
}
T-2 toxin and its metabolites (resulting from enzymatic hydrolysis by rat brain homogenate) were applied to the midbrain of albino rats, either in solid form or dissolved in dimethyl sulfoxide (DMSO). Solid implants of HT-2 toxin and of T-2 triol were lethal in the range of 10-20 micrograms per rat, i.e. similar to the effect of T-2 toxin itself. For four further trichothecenes, the following decreasing order of toxicities was found: T-2 tetraol = iso-T-2 toxin greater than T-2 tetraol… CONTINUE READING
1 Citations
0 References
Similar Papers

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…