Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling.

@article{Beaufort2014CerebralSV,
  title={Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling.},
  author={Nathalie Beaufort and Eva Maria Scharrer and Elisabeth Kremmer and Vanda Lux and Michael Ehrmann and Robert Huber and Henry Houlden and David J Werring and Christof Haffner and Martin Dichgans},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 46},
  pages={16496-501}
}
High temperature requirement protein A1 (HtrA1) is a primarily secreted serine protease involved in a variety of cellular processes including transforming growth factor β (TGF-β) signaling. Loss of its activity causes cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), an inherited form of cerebral small vessel disease leading to early-onset stroke and premature dementia. Dysregulated TGF-β signaling is considered to promote CARASIL… CONTINUE READING
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