Cerebral pharmacodynamics of anaesthetic and subanaesthetic doses of ketamine in the normoventilated pig.

@article{keson1993CerebralPO,
  title={Cerebral pharmacodynamics of anaesthetic and subanaesthetic doses of ketamine in the normoventilated pig.},
  author={Jonas {\AA}keson and Sven Bj{\"o}rkman and Kenneth Messeter and Ingmar Ros{\'e}n and M E Helfer},
  journal={Acta anaesthesiologica Scandinavica},
  year={1993},
  volume={37 2},
  pages={211-8}
}
There are still divergent opinions regarding the pharmacodynamic effects of ketamine on the brain. In this study, the cerebral blood flow (CBF), cerebral metabolic rate for oxygen (CMRO2) and electroencephalographic (EEG) activity were sequentially assessed over 80 min in 17 normoventilated pigs following rapid i.v. infusions of anaesthetic (10.0 mg.kg-1; n = 7) or subanaesthetic (2.0 mg.kg-1; n = 7) doses of ketamine or of its major metabolite norketamine (10.0 mg.kg-1; n = 3). The animals… CONTINUE READING