Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin-labeled MRI.

@article{Hendrich2001CerebralPD,
  title={Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin-labeled MRI.},
  author={Kristy S Hendrich and Patrick M Kochanek and John A Melick and Joanne K Schiding and Kimberly D. Statler and Donald S. Williams and Donald W. Marion and Chien Ho},
  journal={Magnetic resonance in medicine},
  year={2001},
  volume={46 1},
  pages={202-6}
}
The influence of anesthetic agents on cerebral blood flow (CBF) was tested in normal rats. CBF is quantified with arterial spin-labeled MRI in rats anesthetized with either an opiate (fentanyl), a potent inhalation anesthetic agent (isoflurane), or a barbiturate (pentobarbital) using doses commonly employed in experimental paradigms. CBF values were found to be about 2.5-3 times lower in most regions analyzed during anesthesia with either fentanyl (with N(2)O/O(2)) or pentobarbital vs… CONTINUE READING

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