Cerebral perfusion SPET correlated with Braak pathological stage in Alzheimer's disease.

  title={Cerebral perfusion SPET correlated with Braak pathological stage in Alzheimer's disease.},
  author={Kevin Martin Bradley and Valerie O'sullivan and N. J. Soper and Zolt{\'a}n G Nagy and Edward M. King and Alastair D. Smith and Basil Shepstone},
  journal={Brain : a journal of neurology},
  volume={125 Pt 8},
Reductions in regional cerebral perfusion, particularly in the posterior temporo-parietal lobes, are well recognized in Alzheimer's disease. We set out to correlate perfusion changes, using (99m)Tc-HMPAO single photon emission tomography (SPET), with the pathological stage of Alzheimer's disease. The 'Braak stage' of the distribution of neurofibrillary pathology in post-mortem brains was used to classify SPET scans taken in life from a mixed (dementia and control) elderly population into the… CONTINUE READING
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