Cerebral microvessel endothelium is producing endothelin

@article{Yoshimoto1990CerebralME,
  title={Cerebral microvessel endothelium is producing endothelin},
  author={Satonobu Yoshimoto and Yasuki Ishizaki and Hiroki Kurihara and Tomio Sasaki and Sei-itsu Murota},
  journal={Brain Research},
  year={1990},
  volume={508},
  pages={283-285}
}
Endothelin, a potent vasoconstrictor peptide, was recently isolated from the supernatant of the cultured endothelia of the porcine aorta and is now supposed to be the most likely candidate for the endothelium-derived contractile factor (EDCF), which is responsible for the endothelium-dependent vasoconstriction by various stimuli. In this study, the production of endothelin by the endothelia of porcine cerebral microvessels was revealed by the Northern blot analysis with porcine endothelin cDNA… CONTINUE READING
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