Cerebral microvasculature resistance to acute endothelin-1-induced functional down-regulation in rat.

Fig. 1. Effect of ET-1 on blood flowvelocity in rat ventralmidbrain and basilar artery contraction in situ. A) Flow velocity (percent basal; n=4) and B) contraction (percent basal diameter; n=9) in response to continuous 0.1 μMET-1 superfusion. C) Contraction to cumulative serotonin (0.1–10 μM) superfusion in the absence of ET-1 (open bar: percent of basal… CONTINUE READING