Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases.

  title={Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases.},
  author={Paula Grammas and Joseph Martinez and Bradley M. Miller},
  journal={Expert reviews in molecular medicine},
Diseases of the central nervous system (CNS) pose a significant health challenge, but despite their diversity, they share many common features and mechanisms. For example, endothelial dysfunction has been implicated as a crucial event in the development of several CNS disorders, such as Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, multiple sclerosis, human immunodeficiency virus (HIV)-1-associated neurocognitive disorder and traumatic brain injury. Breakdown of the blood… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 60 extracted citations


Publications referenced by this paper.
Showing 1-10 of 160 references

andZhang,W. (2010)ABC transporters and drug efflux at the blood–brain barrier

  • S. Shen
  • Reviews in Neuroscience
  • 2010
Highly Influential
6 Excerpts

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

  • G. A. Rosenberg
  • Lancet Neurology
  • 2009
Highly Influential
4 Excerpts

Blood–brain barrier dysfunction in parkinsonian midbrain in vivo

  • R Kortekaas
  • Annals of Neurology
  • 2005
Highly Influential
5 Excerpts

Tissue inhibitors of matrix metalloproteinases in neuromuscular disease

  • S 158 Lorenzl
  • Journal of the Neurological Sciences
  • 2003
Highly Influential
6 Excerpts

Similar Papers

Loading similar papers…