Cerebral mechanisms and voiding function

  title={Cerebral mechanisms and voiding function},
  author={Ranan Dasgupta and Rajesh Kavia and Clare J. Fowler},
  journal={BJU International},
Some of the most recent work investigating the cerebral mechanisms involved in bladder control has been very helpful in adding to our understanding of bladder dysfunction. The group behind this work, from London, presents a mini‐review which will help to update our knowledge in this area. 

Motor cortical neuromodulation of pelvic floor muscle tone: Potential implications for the treatment of urologic conditions

A proof‐of‐concept study is provided to demonstrate the feasibility of modulating resting PFM activity (tone) as well as SMA activity with noninvasive stimulation of SMA.

Chapter 2: Pathophysiology of neurogenic detrusor overactivity and the symptom complex of “Overactive bladder”

This chapter summarizes the neurophysiological control mechanism that underpins normal lower urinary tract function, emphasizing the importance of the afferent system as a potential therapeutic target.

Spinal Cord Injury and Bladder Dysfunction: New Ideas about an Old Problem

The present paper makes a brief description of LUT control and changes occurring after SCI, and refers to new therapeutic options, including vanniloids and botulinum toxin, and discusses mechanisms of spinal cord repair.

Brain activation in response to bladder filling in healthy adults: An activation likelihood estimation meta‐analysis of neuroimaging studies

A meta‐analysis is to identify brain regions that are commonly activated during bladder filling in healthy adults across different studies to identify which brain regions regulate the process of urine storage.

Regional Cerebral Cortical Atrophy is Related to Urinary Tract Symptoms in Parkinson's Disease

This work aimed to assess whether corticometry or volumetry can identify a pattern of cerebral cortical changes in PD patients with LUTS.

Brain activity during bladder filling and pelvic floor muscle contractions: A study using functional magnetic resonance imaging and synchronous urodynamics

To map the brain activity during bladder filling by functional magnetic resonance imaging using a refined scanning protocol including synchronous urodynamics and pelvic floor muscle contractions.

The bare essentials

The lower urinary tract consists of the bladder and urethra and has just two roles: storage of urine and voiding at appropriate times; a complex neural control system acts like a switching circuit to maintain a reciprocal relationship between the reservoir and continence function.

Real‐time measurement of oxyhemoglobin concentration changes in the frontal micturition area: An fNIRS study

To explore brain activity in the frontal micturition area during natural bladder behavior, fMRI is used for the first time to measure the activity of the amygdala, hippocampus, and other areas of the brain involved in emotion and decision-making.

[Brain imaging and bladder function].

  • R. Sakakibara
  • Psychology, Medicine
    Rinsho shinkeigaku = Clinical neurology
  • 2012
This symposium presents recent neuroimaging findings (PET, SPECT, NIRS) relevant to micturition, which would facilitate to help patients with bladder dysfunction due to brain diseases.

A decade of functional brain imaging applied to bladder control

Development of functional brain imaging in the context of emerging ideas of interoception and a working model of brain activity during bladder filling and emptying is proposed is proposed.



Pain mechanisms and their disorders.

How functional imaging techniques have changed the authors' understanding of normal and abnormal pain mechanisms, how they inform a change in clinical practice and to speculate on possible future clinical uses are summarized.

Functional brain imaging and the bladder: New insights into cerebral control over micturition

This article discusses animal studies, which provided the foundation for the understanding of cerebral control over micturition, and recent human studies, implementing functional brain imaging to enhance the knowledge of this complex phenomenon.

Functional imaging and the central control of the bladder

The regions of the brain that have been implicated in the central control of continence are discussed and higher centers such as the insula, anterior cingulate gyrus, and prefrontal regions are probably involved in the modulation of this control and cognition of bladder sensations.

Cerebral activation during micturition in normal men.

It is concluded that the onset and maintenance of micturition in normal men is associated with a vast network of cortical and subcortical regions, confirming observations from clinical and animal studies.

Cortical representation of the urge to void: a functional magnetic resonance imaging study.

Significant brain activity associated with an increased urge to void was found in the insular cortex, frontal opercula, supplementary motor area, cingulate motor area and SMA, and the SMA/CMA seem to be involved in this process.

Brain responses to changes in bladder volume and urge to void in healthy men.

The findings support the hypothesis that the PAG receives information about bladder fullness and relays this information to areas involved in the control of bladder storage and show that the network of brain regions involved in modulating the perception of the urge to void is distinct from that associated with the appreciation of bladderFullness.

Brain mechanisms of pain affect and pain modulation

  • P. Rainville
  • Psychology, Medicine
    Current Opinion in Neurobiology
  • 2002