Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide.

@article{Rizk2006CerebralIA,
  title={Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide.},
  author={Natalie N. Rizk and Jos{\'e} A. Rafols and Joseph C. Dunbar},
  journal={Brain research},
  year={2006},
  volume={1096 1},
  pages={204-12}
}
Neuronal apoptosis has been demonstrated to be a significant factor in neurological deficiencies associated with diabetes, and these deficiencies are exaggerated following ischemia. Diabetic rats have an increased basal level of apoptosis compared to non-diabetics and it has been previously demonstrated that infarct volumes were greater in diabetic animals following middle cerebral artery occlusion (MCAO) when compared to non-diabetics. In this study, we evaluated both the acute and chronic… CONTINUE READING