Cerebral ischemia and white matter edema in experimental hydrocephalus: a combined in vivo MRI and MRS study

@article{Braun1997CerebralIA,
  title={Cerebral ischemia and white matter edema in experimental hydrocephalus: a combined in vivo MRI and MRS study},
  author={K. P. J. Braun and Rick M. Dijkhuizen and Robin A de Graaf and Klaas Nicolay and W. Peter Vandertop and R. H. J. M. Gooskens and Kees A. F Tulleken},
  journal={Brain Research},
  year={1997},
  volume={757},
  pages={295-298}
}
T2 and diffusion weighted MRI, as well as 31P and 1H MRS were performed in kaolin-induced hydrocephalic rats. Extracellular white matter edema was detected in the early stages of progressive hydrocephalus. Phosphocreatine (PCr)/inorganic phosphate (Pi) ratios in hydrocephalic animals were decreased compared to controls, and lactate was detected during the acute and chronic stages of hydrocephalus. These MR spectroscopic results are indicative of a compromised energy metabolism and suggest the… CONTINUE READING
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