Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function.

@article{Grobe2005CerebralHA,
  title={Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function.},
  author={Kay Grobe and Masaru Inatani and Srinivas Reddy Pallerla and Jan Castagnola and Yu Yamaguchi and Jeffrey D Esko},
  journal={Development},
  year={2005},
  volume={132 16},
  pages={3777-86}
}
Mutant mice bearing a targeted disruption of the heparan sulfate (HS) modifying enzyme GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) exhibit severe developmental defects of the forebrain and forebrain-derived structures, including cerebral hypoplasia, lack of olfactory bulbs, eye defects and axon guidance errors. Neural crest-derived facial structures are also severely affected. We show that properly synthesized heparan sulfate is required for the normal development of the brain and face… CONTINUE READING
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