Cerebral hypoperfusion and cognitive impairment: the pathogenic role of vascular oxidative stress.

@article{Liu2012CerebralHA,
  title={Cerebral hypoperfusion and cognitive impairment: the pathogenic role of vascular oxidative stress.},
  author={Hui Liu and Junjian Zhang},
  journal={The International journal of neuroscience},
  year={2012},
  volume={122 9},
  pages={494-9}
}
Alzheimer's disease (AD) and vascular dementia (VaD) are the most frequent causes of cognitive impairment in the elderly. In the pathogenesis of cognitive impairment, the association of neurodegenerative and vascular factors indicates a major role of hemodynamic abnormalities including cerebral hypoperfusion. There is also ample evidence that oxidative stress of vascular origin leads to profound alterations in cerebrovascular regulation and is crucial to cerebrovascular dysfunction in a variety… CONTINUE READING