Cerebral hyperemia, stroke, and transfusion in sickle cell disease.

  title={Cerebral hyperemia, stroke, and transfusion in sickle cell disease.},
  author={Isak Prohovnik and Steven G. Pavlakis and Sergio Piomelli and J. Ram{\'i}rez Bello and Jay P. Mohr and S D Hilal and Darryl C. De Vivo},
  volume={39 3},
To investigate cerebral hemodynamics in sickle cell disease (SCD), we used the 133Xenon inhalation technique of quantifying cerebral blood flow (CBF) in 67 patients. Clinical examinations and cerebral magnetic resonance imaging also were performed in all patients. Compared with age-matched healthy controls, CBF was elevated by 68% in patients, and inversely related to hematocrit. An experimental index of cerebral blood volume, pr4, was also elevated in the patients in a similar manner. Cerebral… CONTINUE READING


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