Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration.

@article{Clemmesen1999CerebralHI,
  title={Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration.},
  author={J O Clemmesen and Fin Stolze Larsen and Jens Kondrup and Bent Adel Hansen and Peter Ott},
  journal={Hepatology},
  year={1999},
  volume={29 3},
  pages={648-53}
}
Cerebral edema leading to cerebral herniation (CH) is a common cause of death in acute liver failure (ALF). Animal studies have related ammonia with this complication. During liver failure, hepatic ammonia removal can be expected to determine the arterial ammonia level. In patients with ALF, we examined the hypotheses that high arterial ammonia is related to later death by CH, and that impaired removal in the hepatic circulation is related to high arterial ammonia. Twenty-two patients with ALF… CONTINUE READING
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