Cerebral hemodynamic reserve and vascular remodeling in C57/BL6 mice are influenced by age.

@article{Hecht2012CerebralHR,
  title={Cerebral hemodynamic reserve and vascular remodeling in C57/BL6 mice are influenced by age.},
  author={N. K. Hecht and Jin He and Irina Kremenetskaia and Melina Nieminen and Peter Vajkoczy and Johannes Woitzik},
  journal={Stroke},
  year={2012},
  volume={43 11},
  pages={3052-62}
}
BACKGROUND AND PURPOSE Age is the most important risk factor for ischemic stroke. Recent experiments evidenced an age-associated rarefaction of the native collateral vasculature. The purpose of this study was to assess in what way age and arteriogenesis influence cortical perfusion and recovery of hemodynamic impairment in aged and young C57/BL6 mice. METHODS After model establishment of chronic cerebral hypoperfusion in the C57/BL6 strain, sustained hemodynamic impairment was induced by… CONTINUE READING
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