Cerebral hemodynamic effects of 7.2% hypertonic saline in patients with head injury and raised intracranial pressure.

@article{Munar2000CerebralHE,
  title={Cerebral hemodynamic effects of 7.2% hypertonic saline in patients with head injury and raised intracranial pressure.},
  author={Francisca Munar and Ana Maria Ferrer and Miriam de Nadal and M A Poca and Salvador Pedraza and Juan Sahuquillo and Angel Garnacho},
  journal={Journal of neurotrauma},
  year={2000},
  volume={17 1},
  pages={41-51}
}
The aim of the present study was to investigate the acute effects of 7.2% hypertonic saline (HS) on intracranial pressure (ICP), cerebral and systemic hemodynamics, serum sodium, and osmolality in 14 patients with moderate and severe traumatic brain injury (Glasgow Coma Scale < or =13) and raised ICP (>15 mm Hg) within the first 72 h postinjury. After CO2 reactivity and autoregulation were tested, each patient received a 15-min infusion of 7.2% HS (1,232 mEq/L, volume 1.5 mL/kg). ICP, serial… CONTINUE READING