Cerebral folate deficiency

  title={Cerebral folate deficiency},
  author={Neil S. Gordon},
  journal={Developmental Medicine \& Child Neurology},
  • N. Gordon
  • Published 1 March 2009
  • Medicine, Biology, Psychology
  • Developmental Medicine & Child Neurology
Cerebral folate deficiency (CFD) is associated with low levels of 5‐methyltetrahydrofolate in the cerebrospinal fluid (CSF) with normal folate levels in the plasma and red blood cells. The onset of symptoms caused by the deficiency of folates in the brain is at around 4 to 6 months of age. This is followed by delayed development, with deceleration of head growth, hypotonia, and ataxia, followed in one‐third of children by dyskinesias (choreo‐athetosis, hemiballismus), spasticity, speech… 
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