Cerebral extraction of N-13 ammonia: its dependence on cerebral blood flow and capillary permeability -- surface area product.

@article{Phelps1981CerebralEO,
  title={Cerebral extraction of N-13 ammonia: its dependence on cerebral blood flow and capillary permeability -- surface area product.},
  author={Michael E. Phelps and Sung-cheng Huang and Edward J. Hoffman and C J Selin and David E. Kuhl},
  journal={Stroke},
  year={1981},
  volume={12 5},
  pages={
          607-19
        }
}
13N-labeled ammonia was used to investigate 1) the cerebral extraction and clearance of ammonia, 2) the mechanism by which capillaries accommodate changes in cerebral blood flow (CBF) and 3) its use for the measurement of CBF. The unidirectional extraction of 13NH3 in rhesus monkeys was measured during PaCO2 induced changes in CBF and dog studies were performed using in vitro tissue counting techniques to examine 13NH3 extraction in gray and white matter, mixed tissue and cerebellum during… CONTINUE READING
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