Cerebral extracellular lactate increase is predominantly nonischemic in patients with severe traumatic brain injury.

@article{Sala2013CerebralEL,
  title={Cerebral extracellular lactate increase is predominantly nonischemic in patients with severe traumatic brain injury.},
  author={Nathalie Sala and Tamarah Suys and J. B. Zerlauth and Pierre Bouzat and Mahmoud Messerer and Jocelyne Bloch and Marc Levivier and Pierre J. Magistretti and Reto Meuli and Mauro Oddo},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2013},
  volume={33 11},
  pages={1815-22}
}
Growing evidence suggests that endogenous lactate is an important substrate for neurons. This study aimed to examine cerebral lactate metabolism and its relationship with brain perfusion in patients with severe traumatic brain injury (TBI). A prospective cohort of 24 patients with severe TBI monitored with cerebral microdialysis (CMD) and brain tissue oxygen tension (PbtO2) was studied. Brain lactate metabolism was assessed by quantification of elevated CMD lactate samples (>4 mmol/L); these… CONTINUE READING

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