Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice.

@article{Kemppainen2015CerebralDN,
  title={Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice.},
  author={Susanna Kemppainen and P{\"a}ivi Lindholm and Emilia Galli and H. Lahtinen and Henna Koivisto and Elina H{\"a}m{\"a}l{\"a}inen and Mart Saarma and Heikki Tanila},
  journal={Behavioural brain research},
  year={2015},
  volume={291},
  pages={1-11}
}
Cerebral dopamine neurotrophic factor (CDNF) protects and repairs dopamine neurons in animal models of Parkinson's disease, which motivated us to investigate its therapeutic effect in an animal model of Alzheimer's disease (AD). We employed an established APP/PS1 mouse model of AD and gave intrahippocampal injections of CDNF protein or CDNF transgene in an… CONTINUE READING