Cerebral demyelination with 5-fluorouracil and levamisole.

  title={Cerebral demyelination with 5-fluorouracil and levamisole.},
  author={Athanasios B-T Fassas and Abhishek Gattani and Susan Morgello},
  journal={Cancer investigation},
  volume={12 4},
We report a patient who developed multifocal cerebral demyelination with the use of 5-fluorouracil, levamisole, and leucovorin as adjuvant treatment for intestinal adenocarcinoma. The clinical features were acute confusion, restlessness, ataxia, and slurred speech. Magnetic resonance imaging revealed multifocal enhancing white matter lesions. Brain biopsy showed a well-demarcated area of demyelination in cerebral white matter. The patient improved clinically and radiologically after cessation… CONTINUE READING


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