Cerebral creatine kinase deficiency influences metabolite levels and morphology in the mouse brain: a quantitative in vivo 1H and 31P magnetic resonance study.

@article{Zandt2004CerebralCK,
  title={Cerebral creatine kinase deficiency influences metabolite levels and morphology in the mouse brain: a quantitative in vivo 1H and 31P magnetic resonance study.},
  author={Henricus J A In 't Zandt and W. Klaas Jan Renema and Femke Streijger and Carolina Jost and Dennis W. J. Klomp and Frank T. J. J. Oerlemans and Catharina E.E.M. Van der Zee and B E Wieringa and Arend Heerschap},
  journal={Journal of neurochemistry},
  year={2004},
  volume={90 6},
  pages={1321-30}
}
Creatine kinase (CK)-catalysed ATP-phosphocreatine (PCr) exchange is considered to play a key role in energy homeostasis of the brain. This study assessed the metabolic and anatomical consequences of partial or complete depletion of this system in transgenic mice without cytosolic B-CK (B-CK-/-), mitochondrial ubiquitous CK (UbCKmit-/-), or both isoenzymes (CK -/-), using non-invasive quantitative magnetic resonance (MR) imaging and spectroscopy. MR imaging revealed an increase in ventricle… CONTINUE READING