Cerebral correlates of cognitive reserve.

  title={Cerebral correlates of cognitive reserve.},
  author={Lawrence J. Whalley and Roger T. Staff and Helen C. Fox and Alison D. Murray},
  journal={Psychiatry research. Neuroimaging},
Cognitive reserve is a hypothetical concept introduced to explain discrepancies between severity of clinical dementia syndromes and the extent of dementia pathology. We examined cognitive reserve in a research programme that followed up a non-clinical sample born in 1921 or 1936 and IQ-tested age 11 years in 1932 or 1947. Structural MRI exams were acquired in about 50% of the sample from whom a subsample were recruited into an additional fMRI study. Here, we summarise findings from seven inter… CONTINUE READING