Cerebral circulation and histamine: 2. Responses of pial veins and arterioles to receptor agonists.

@article{Gross1981CerebralCA,
  title={Cerebral circulation and histamine: 2. Responses of pial veins and arterioles to receptor agonists.},
  author={Paul M. Gross and Ann M. Harper and Graham M. Teasdale},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1981},
  volume={1 2},
  pages={219-25}
}
H2-receptors predominantly mediate pial arteriolar dilatation in response to histamine, but the reaction of pial veins to histamine has not been clearly identified. In anesthetized cats, we examined responses of pial veins and arterioles to perivascular microapplication of histamine and specific histamine H1 and H2 receptor agonists. Arterioles were very sensitive to the H2-receptor agonist impromidine, with significant dilatation (+16%) occurring at concentrations as low as 10(-10) M… CONTINUE READING