Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

  title={Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity},
  author={Rebecca A. Stockton and Robert Shenkar and I A Awad and Mark H Ginsberg},
  booktitle={The Journal of experimental medicine},
Endothelial cell-cell junctions regulate vascular permeability, vasculogenesis, and angiogenesis. Familial cerebral cavernous malformations (CCMs) in humans result from mutations of CCM2 (malcavernin, OSM, MGC4607), PDCD10 (CCM3), or KRIT1 (CCM1), a Rap1 effector which stabilizes endothelial cell-cell junctions. Homozygous loss of KRIT1 or CCM2 produces lethal vascular phenotypes in mice and zebrafish. We report that the physical interaction of KRIT1 and CCM2 proteins is required for… CONTINUE READING
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