Cerebral blood volume measurements by T*2-weighted MRI and contrast infusion.

@article{Newman2003CerebralBV,
  title={Cerebral blood volume measurements by T*2-weighted MRI and contrast infusion.},
  author={George Charles Newman and Evan Delucia-Deranja and Alina Tudorica and Frank E Hospod and Clifford S. Patlak},
  journal={Magnetic resonance in medicine},
  year={2003},
  volume={50 4},
  pages={844-55}
}
A reliable, accurate, and accessible method for measuring cerebral blood volume (CBV) has been developed based on T(*) (2)-weighted MRI and a 1-min infusion of gadolinium instead of a bolus. Computer simulations predict that this infusion CBV method will have a signal-to-noise ratio (SNR) 3-5 times greater than that obtained by area-under-the-curve (AUC) methods, with high accuracy over a wide range of arterial, tissue, and MRI conditions. In six healthy controls, the CBV was 1.87 +/- 0.44 in… CONTINUE READING
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