Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: a [(15)O] H2O PET study.

@article{Ballanger2009CerebralBF,
  title={Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: a [(15)O] H2O PET study.},
  author={B{\'e}n{\'e}dicte Ballanger and Andres M. Lozano and Elena Moro and Thilo van Eimeren and Clement Hamani and Robert Chen and Roberto Cilia and Sylvain Houle and Yu Yan Poon and Anthony E Lang and Antonio P. Strafella},
  journal={Human brain mapping},
  year={2009},
  volume={30 12},
  pages={3901-9}
}
Patients with advanced Parkinson's disease (PD) develop disabling axial symptoms, including gait disturbances, freezing and postural instability poorly responsive to levodopa replacement therapy. The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement sleep]. Recent reports suggested that PPN modulation with deep brain stimulation (DBS) may be beneficial in the treatment of axial symptoms. However, the… CONTINUE READING

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