Cerebral blood flow and oxygen delivery during hypoxemia and hemodilution: role of arterial oxygen content.

@article{Todd1994CerebralBF,
  title={Cerebral blood flow and oxygen delivery during hypoxemia and hemodilution: role of arterial oxygen content.},
  author={Michael M. Todd and Bing-qin Wu and Mazen A. Maktabi and Bradley J. Hindman and David Sjoquist Nick Warner},
  journal={The American journal of physiology},
  year={1994},
  volume={267 5 Pt 2},
  pages={
          H2025-31
        }
}
To determine the role of arterial O2 content (CaO2) in the cerebral blood flow (CBF) responses to hypoxemia and hemodilution, CaO2 was progressively reduced from approximately 18 to approximately 6 ml O2/dl in normocapnic, normothermic, pentobarbital-anesthetized rabbits. This was done either by reducing PaO2 (hypoxemia, minimum PaO2 approximately 26 mmHg) or arterial hematocrit (isovolemic hemodilution with hetastarch, minimum hematocrit approximately 14%) while CBF was measured with… CONTINUE READING
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