Cerebral blood flow and oxygen consumption in man.

@article{Lassen1959CerebralBF,
  title={Cerebral blood flow and oxygen consumption in man.},
  author={N. Lassen},
  journal={Physiological reviews},
  year={1959},
  volume={39 2},
  pages={
          183-238
        }
}
  • N. Lassen
  • Published 1959
  • Medicine
  • Physiological reviews
HE BLOOD FLOW AND OXYGEN METABOLISM of the human brain has been studied intensively since Kety developed the inert gas method in 1945. More than 200 clinical studies employing this method have been published so far, and now the former terra incognita is well mapped out. The information gained from all these studies will form the subject of the present review. It will also include, however, the results obtained by an indicator injection technique which has been applied to the measurement of… Expand
Historical Review of Developments in the Field of Cerebral Blood Flow and Metabolism
Brain (cerebral) blood flow (CBF) and metabolism have long been subjects of great interest, but progress in their study awaited development of quantitative methods applicable to unanesthetizedExpand
Measurement of cerebral blood flow in man.
  • A. Harper
  • Medicine
  • Scottish medical journal
  • 1967
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Measurement of cerebral blood flow (CBF) is based on the use of freely diffusible indicators, which reach the brain tissue by the arterial system and give rise to a fast and complete equivalence inExpand
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In 1945 Kety in collaboration with Schmidt developed the nitrous oxide method for measuring the average cerebral blood flow (CBF) and the average cerebral metabolic rate of oxygen (CMRO2) in man1.Expand
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TCD further progressed the understanding of CBF regulation and allowed for insight into other mechanistic factors, independent of local metabolism, involved in regulating CBF during exercise. Expand
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The diffusibility of C02 is such that it easily distributes in all tissue compartments, and the reactions underlying the mechanism of action may be entirely confined to the cells of the vessel walls, so it appears worthwhile to consider also the acid-base changes of the extracellular fluid. Expand
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The relation between pCOz and cerebral blood flow (CBF) has been known for many years and the correlation ceases with low oxygen tensions in the brain, and the 0 2 correlation acts as a safetyvalve in cases with reduced oxygen capacity of the blood. Expand
Cerebral blood flow during convulsions. Alterations induced in animals by high pressure oxygen.
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The heated thermocouple technique, a refinement of the method used in earlier blood flow studies 2 has been used for continuously recording any regional changes in blood flow from chronically implanted flow sensors to get further and more direct evidence concerning such changes in CBF in the rat. Expand
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